Rapid Progression to Simian AIDS Can Be Accompanied by Selection of CD4-Independent gp120 Variants with Impaired Ability To Bind CD4

Aspartate 368 on human immunodeficiency virus type 1 (HIV-1) gp120 forms multiple contacts with CD4; in mutagenesis studies, its replacement by asparagine and corresponding changes in simian immunodeficiency virus SIVmac (D385N) reduced binding with CD4. Nevertheless, simian immunodeficiency virus e...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Ryzhova, Elena, Whitbeck, J. Charles, Canziani, Gabriela, Westmoreland, Susan V., Cohen, Gary H., Eisenberg, Roselyn J., Lackner, Andrew, González-Scarano, Francisco
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136356/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12097605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.15.7903-7909.2002
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