Antibody-Mediated Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Determined by the Structure of gp120 and Depends on Modulation of the gp120-CCR5 Interaction

In this study, we characterized the viral determinants of coreceptor usage in relation to susceptibility to antibody-mediated neutralization or enhancement of infectivity by using chimeras of three highly related human immunodeficiency virus type 1 (HIV-1) isolates of different phenotypes. We found...

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Bibliographic Details
Main Authors: Guillon, Christophe, Schutten, Martin, Boers, Patrick H. M., Gruters, Rob A., Osterhaus, Albert D. M. E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135957/
https://ncbi.nlm.nih.gov/pubmed/11861850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.6.2827-2834.2002
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