Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size

Gene therapy vectors based on adeno-associated viruses (AAVs) show promise for the treatment of retinal degenerative diseases. In prior work, subretinal injections of AAV2, AAV5, and AAV2 pseudotyped with AAV5 capsids (AAV2/5) showed variable retinal pigmented epithelium (RPE) and photoreceptor cell...

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Pubblicato in:	J Virol
Autori principali:	Yang, Grace S., Schmidt, Michael, Yan, Ziying, Lindbloom, Jonathan D., Harding, Thomas C., Donahue, Brian A., Engelhardt, John F., Kotin, Robert, Davidson, Beverly L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Gene Therapy
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12097579/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.15.7651-7660.2002
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