Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size

Gene therapy vectors based on adeno-associated viruses (AAVs) show promise for the treatment of retinal degenerative diseases. In prior work, subretinal injections of AAV2, AAV5, and AAV2 pseudotyped with AAV5 capsids (AAV2/5) showed variable retinal pigmented epithelium (RPE) and photoreceptor cell...

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Main Authors: Yang, Grace S., Schmidt, Michael, Yan, Ziying, Lindbloom, Jonathan D., Harding, Thomas C., Donahue, Brian A., Engelhardt, John F., Kotin, Robert, Davidson, Beverly L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136354/
https://ncbi.nlm.nih.gov/pubmed/12097579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.15.7651-7660.2002
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