Analysis of a Temperature-Sensitive Mutant Rotavirus Indicates that NSP2 Octamers Are the Functional Form of the Protein

Evidence that NSP2 plays a role in packaging and replication comes from studies on tsE(1400), a rotavirus mutant with a temperature-sensitive (ts) lesion in the NSP2 gene. Cells infected with tsE and maintained at nonpermissive temperature contain few replication-assembly factories (viroplasms) or r...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Taraporewala, Zenobia F., Schuck, Peter, Ramig, Robert F., Silvestri, Lynn, Patton, John T.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Replication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136338/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12072508/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.14.7082-7093.2002
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