Immunization of Rhesus Macaques with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen Induces Broad Simian Immunodeficiency Virus (SIV)-Specific T-Cell Responses and Reduces Initial Viral Replication but Does Not Prevent Disease Progression following Challenge with Pathogenic SIVmac239

Producing a prophylactic vaccine for human immunodeficiency virus (HIV) has proven to be a challenge. Most biological isolates of HIV are difficult to neutralize, so that conventional subunit-based antibody-inducing vaccines are unlikely to be very effective. In the rhesus macaque model, some protec...

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Main Authors: Horton, Helen, Vogel, Thorsten U., Carter, Donald K., Vielhuber, Kathy, Fuller, Deborah H., Shipley, Tim, Fuller, James T., Kunstman, Kevin J., Sutter, Gerd, Montefiori, David C., Erfle, Volker, Desrosiers, Ronald C., Wilson, Nancy, Picker, Louis J., Wolinsky, Steven M., Wang, Chenxi, Allison, David B., Watkins, David I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC136301/
https://ncbi.nlm.nih.gov/pubmed/12072518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.14.7187-7202.2002
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