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Muscarinic Receptor Activation Protects Cells from Apoptotic Effects of DNA Damage, Oxidative Stress, and Mitochondrial Inhibition

The impact of muscarinic receptor stimulation was examined on apoptotic signaling induced by DNA damage, oxidative stress, and mitochondrial impairment. Exposure of human neuroblastoma SH-SY5Y cells to the DNA-damaging agent camptothecin increased p53 levels, activated caspase-3, and caused cell dea...

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Detalhes bibliográficos
Main Authors: De Sarno, Patrizia, Shestopal, Svetlana A., King, Taj D., Zmijewska, Anna, Song, Ling, Jope, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361698/
https://ncbi.nlm.nih.gov/pubmed/12538580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M212157200
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