Mechanism of Rhodopsin Activation as Examined with Ring-constrained Retinal Analogs and the Crystal Structure of the Ground State Protein

The guanine nucleotide-binding protein (G-protein)-coupled receptor superfamily (GPCR) is comprised of a large group of membrane proteins involved in a wide range of physiological signaling processes. The functional switch from a quiescent to an active conformation is at the heart of GPCR action. Th...

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Main Authors: Jang, Geeng-Fu, Kuksa, Vladimir, Filipek, Stawomir, Bartl||, Franz, Ritter, Eglof, Gelb, Michael H., Hofmann, Klaus Peter, Palczewski, Krzysztof
Format: Artigo
Language:Inglês
Published: 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361691/
https://ncbi.nlm.nih.gov/pubmed/11316815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M102212200
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