The dicistronic RNA from the mouse LINE-1 retrotransposon contains an internal ribosome entry site upstream of each ORF: implications for retrotransposition

Most eukaryotic mRNAs are monocistronic and translated by cap-dependent initiation. LINE-1 RNA is exceptional because it is naturally dicistronic, encoding two proteins essential for retrotransposition, ORF1p and ORF2p. Here, we show that sequences upstream of ORF1 and ORF2 in mouse L1 function as i...

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Bibliographic Details
Main Authors: Li, Patrick Wai-Lun, Li, Jinfang, Timmerman, Stephanie L., Krushel, Les A., Martin, Sandra L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361618/
https://ncbi.nlm.nih.gov/pubmed/16464823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj490
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