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Transcriptional Downregulation of ORF50/Rta by Methotrexate Inhibits the Switch of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 from Latency to Lytic Replication

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cellular dihydrofolate reductase (DHFR) homologue. Methotrexate (MTX), a potent anti-inflammatory agent, inhibits cellular DHFR activity. We investigated the effect of noncytotoxic doses of MTX on latency and lytic KSHV replication in two KSHV...

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Udgivet i:J Virol
Principais autores: Curreli, Francesca, Cerimele, Francesca, Muralidhar, Sumitra, Rosenthal, Leonard J., Cesarman, Ethel, Friedman-Kien, Alvin E., Flore, Ornella
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136151/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11967335/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.10.5208-5219.2002
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