Transcriptional Downregulation of ORF50/Rta by Methotrexate Inhibits the Switch of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 from Latency to Lytic Replication

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cellular dihydrofolate reductase (DHFR) homologue. Methotrexate (MTX), a potent anti-inflammatory agent, inhibits cellular DHFR activity. We investigated the effect of noncytotoxic doses of MTX on latency and lytic KSHV replication in two...

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Detalhes bibliográficos
Main Authors: Curreli, Francesca, Cerimele, Francesca, Muralidhar, Sumitra, Rosenthal, Leonard J., Cesarman, Ethel, Friedman-Kien, Alvin E., Flore, Ornella
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136151/
https://ncbi.nlm.nih.gov/pubmed/11967335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.10.5208-5219.2002
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