The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFβ1 responses in human proximal-tubule epithelial cells

In chronic renal diseases, progressive loss of renal function correlates with advancing tubulo-interstitial fibrosis. TGFβ1-Smad (transforming growth factor-β1–Sma and Mad protein) signalling plays an important role in the development of renal tubulo-interstitial fibrosis. Secretion of CTGF (connect...

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Main Authors: Phanish, Mysore K., Wahab, Nadia A., Colville-Nash, Paul, Hendry, Bruce M., Dockrell, Mark E. C.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2005
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360711/
https://ncbi.nlm.nih.gov/pubmed/16253118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051106
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