Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis

Type II fatty acid biosynthesis represents an attractive target for the discovery of new antimalarial drugs. Previous studies have identified malarial ENR (enoyl acyl-carrier-protein reductase, or FabI) as the target for the antiseptic triclosan. In the present paper, we report the biochemical prope...

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Autors principals: Wickramasinghe, Sasala R., Inglis, Kirstine A., Urch, Jonathan E., Müller, Sylke, van Aalten, Daan M. F., Fairlamb, Alan H.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2005
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360695/
https://ncbi.nlm.nih.gov/pubmed/16225460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050832
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