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MMP9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment

The role of specific stromal-derived MMPs was analyzed in experimental metastasis assays in wildtype and either MMP9, MMP7, or MMP2 null mice. MMP9 null mice showed an 81% reduction in Lewis Lung Carcinoma tumor number, while MMP7 null mice showed a 42% increase in tumor number and there was no diff...

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Detalhes bibliográficos
Main Authors: Acuff, Heath B., Carter, Kathy J., Fingleton, Barbara, Gorden, D. Lee, Matrisian, Lynn M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360653/
https://ncbi.nlm.nih.gov/pubmed/16397239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-2502
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