Expression of Simian Immunodeficiency Virus nef in Immune Cells of Transgenic Mice Leads to a Severe AIDS-Like Disease

In order to study the functions of simian immunodeficiency virus (SIV) Nef in vivo in a small-animal model, we constructed transgenic (Tg) mice expressing the SIV(mac)239 nef gene in the natural target cells of the virus under the control of the human CD4 gene promoter (CD4C). These CD4C/SHIV-nef(SI...

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書誌詳細

出版年:	J Virol
主要な著者:	Simard, Marie-Chantal, Chrobak, Pavel, Kay, Denis G., Hanna, Zaher, Jothy, Serge, Jolicoeur, Paul
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 2002
主題:	Pathogenesis and Immunity
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11907238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.8.3981-3995.2002
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