Expression of Simian Immunodeficiency Virus nef in Immune Cells of Transgenic Mice Leads to a Severe AIDS-Like Disease

In order to study the functions of simian immunodeficiency virus (SIV) Nef in vivo in a small-animal model, we constructed transgenic (Tg) mice expressing the SIV(mac)239 nef gene in the natural target cells of the virus under the control of the human CD4 gene promoter (CD4C). These CD4C/SHIV-nef(SI...

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Publié dans:	J Virol
Auteurs principaux:	Simard, Marie-Chantal, Chrobak, Pavel, Kay, Denis G., Hanna, Zaher, Jothy, Serge, Jolicoeur, Paul
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Pathogenesis and Immunity
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11907238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.8.3981-3995.2002
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