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Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia

Genetically primed adult C57BL mice were deleted of exon 5 of the gene encoding the transcription factor PU.1 by IFN activation of Cre recombinase. After a 13-week delay, conditionally deleted (PU.1(-/-)) mice began dying of myeloid leukemia, and 95% of the mice surviving from early postinduction de...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Metcalf, Donald, Dakic, Aleksandar, Mifsud, Sandra, Di Rago, Ladina, Wu, Li, Nutt, Stephen
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2006
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360594/
https://ncbi.nlm.nih.gov/pubmed/16432184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510616103
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