The methyl-CpG binding protein MBD1 is required for PML-RARα function

PML-RARα induces a block of hematopoietic differentiation and acute promyelocytic leukemia. This block is based on its capacity to inactivate target genes by recruiting histone deacetylase (HDAC) and DNA methyltransferase activities. Here we report that MBD1, a member of a conserved family of protei...

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Autors principals: Villa, Raffaella, Morey, Lluis, Raker, Veronica A., Buschbeck, Marcus, Gutierrez, Arantxa, De Santis, Francesca, Corsaro, Massimo, Varas, Florencio, Bossi, Daniela, Minucci, Saverio, Pelicci, Pier Giuseppe, Di Croce, Luciano
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360559/
https://ncbi.nlm.nih.gov/pubmed/16432238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509343103
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