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Inhibition of Hepatitis B Virus Replication by Interferon Requires Proteasome Activity†

Hepatitis B virus (HBV) replication is inhibited in a noncytopathic manner by alpha/beta interferon (IFN-α/β) and IFN-γ. We demonstrate here that inhibitors of cellular proteasome activity can block this antiviral effect. These results suggest that a critical component of the IFN-induced antiviral r...

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Détails bibliographiques
Auteurs principaux: Robek, Michael D., Wieland, Stefan F., Chisari, Francis V.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC136040/
https://ncbi.nlm.nih.gov/pubmed/11884582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.7.3570-3574.2002
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