Upregulation of Immunoregulatory Src Homology 2 Molecule Containing Inositol Phosphatase and Mononuclear Cell Hyporesponsiveness in Oral Mucosa during Chronic Periodontitis

Our group and others have shown in vitro that repeated exposure of human mononuclear cells (MNC) to lipopolysaccharide can induce endotoxin tolerance, evidenced by downregulation of TLR2 and TLR4 mRNA and surface protein; moreover, the ability of the MNC to secrete inflammatory cytokines is reduced....

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Bibliographische Detailangaben
Hauptverfasser: Muthukuru, Manoj, Cutler, Christopher W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360327/
https://ncbi.nlm.nih.gov/pubmed/16428799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.2.1431-1435.2006
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