Derivation and Characterization of a Dengue Type 1 Host Range-Restricted Mutant Virus That Is Attenuated and Highly Immunogenic in Monkeys

We recently described the derivation of a dengue serotype 2 virus (DEN2mutF) that exhibited a host range-restricted phenotype; it was severely impaired for replication in cultured mosquito cells (C6/36 cells). DEN2mutF virus had selected mutations in genomic sequences predicted to form a 3′ stem-loo...

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Detalhes bibliográficos
Main Authors: Markoff, Lewis, Pang, Xiaou, Houng, Huo-shu, Falgout, Barry, Olsen, Raymond, Jones, Estella, Polo, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136019/
https://ncbi.nlm.nih.gov/pubmed/11884557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.7.3318-3328.2002
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