NKT cell stimulation with glycolipid antigen in vivo: co-stimulation-dependent expansion, Bim-dependent contraction, and hypo-responsiveness to further antigenic challenge

Activation of NKT cells using the glycolipid α-galactosylceramide (α-GalCer()) has availed many investigations into their immunoregulatory and therapeutic potential. However, it remains unclear how NKT cells respond to stimulation in vivo, which co-stimulatory pathways are important, and what factor...

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Bibliographic Details
Main Authors:	Uldrich, Adam P., Crowe, Nadine Y., Kyparissoudis, Konstantinos, Pellicci, Daniel G., Zhan, Yifan, Lew, Andrew M., Bouillet, Philippe, Strasser, Andreas, Smyth, Mark J., Godfrey, Dale I.
Format:	Artigo
Language:	Inglês
Published:	2005
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1360163/ https://ncbi.nlm.nih.gov/pubmed/16116198
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NKT cell stimulation with glycolipid antigen in vivo: co-stimulation-dependent expansion, Bim-dependent contraction, and hypo-responsiveness to further antigenic challenge

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