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Sequence, Distance, and Accessibility are Determinants of 5′ End-Directed Cleavages by Retroviral RNases H

The RNase H activity of reverse transcriptase is essential for retroviral replication. RNA 5′ end-directed cleavages represent a form of RNase H activity that is carried out on RNA/DNA hybrids that contain a recessed RNA 5′. Previously, the distance from the RNA 5′ end has been considered the primar...

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Detalhes bibliográficos
Main Authors: Schultz, Sharon J., Zhang, Miaohua, Champoux, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360142/
https://ncbi.nlm.nih.gov/pubmed/16306040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M510504200
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