CD4 Independence of Simian Immunodeficiency Virus Envs Is Associated with Macrophage Tropism, Neutralization Sensitivity, and Attenuated Pathogenicity

To investigate the basis for envelope (Env) determinants influencing simian immunodeficiency virus (SIV) tropism, we studied a number of Envs that are closely related to that of SIVmac239, a pathogenic, T-tropic virus that is neutralization resistant. The Envs from macrophage-tropic (M-tropic) virus...

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Main Authors: Puffer, Bridget A., Pöhlmann, Stefan, Edinger, Aimee L., Carlin, Dan, Sanchez, Melissa D., Reitter, Julie, Watry, Debbie D., Fox, Howard S., Desrosiers, Ronald C., Doms, Robert W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC135960/
https://ncbi.nlm.nih.gov/pubmed/11861825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.6.2595-2605.2002
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