A Replication-Competent, Neutralization-Sensitive Variant of Simian Immunodeficiency Virus Lacking 100 Amino Acids of Envelope

Coding sequences for the first two variable loops of the gp120 envelope glycoprotein were removed from simian immunodeficiency virus (SIV) strain 239 (SIVmac239). This deletion encompassed 100 amino acids. The resulting virus replicated poorly after transfection into immortalized T-cell lines, with...

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Auteurs principaux: Johnson, Welkin E., Morgan, Jennifer, Reitter, Julie, Puffer, Bridget A., Czajak, Susan, Doms, Robert W., Desrosiers, Ronald C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC135934/
https://ncbi.nlm.nih.gov/pubmed/11836385
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