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Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt

To determine whether endothelial Akt could affect vascular lesion formation, mutant mice with a constitutively active Akt transgene, which could be inducibly targeted to the vascular endothelium using the tet-off system (EC-Akt Tg mice), were generated. After withdrawal of doxycycline, EC-Akt Tg mic...

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Hlavní autoři: Mukai, Yasushi, Rikitake, Yoshiyuki, Shiojima, Ichiro, Wolfrum, Sebastian, Satoh, Minoru, Takeshita, Kyosuke, Hiroi, Yukio, Salomone, Salvatore, Kim, Hyung-Hwan, Benjamin, Laura E., Walsh, Kenneth, Liao, James K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2006
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1359051/
https://ncbi.nlm.nih.gov/pubmed/16453020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26223
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