Deficiencies in the Acute-Phase Cell-Mediated Immune Response to Viral Antigens Are Associated with Development of Chronic Woodchuck Hepatitis Virus Infection following Neonatal Inoculation

In vitro proliferation of peripheral blood mononuclear cells was used to measure virus-specific cell-mediated immunity (vCMI) following neonatal woodchuck hepatitis virus (WHV) infection. Fifteen neonates were inoculated with the W8 strain of WHV. In 11, infection was resolved, and 4 became chronic...

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Bibliographic Details
Main Authors: Menne, Stephan, Roneker, Carol A., Roggendorf, Michael, Gerin, John L., Cote, Paul J., Tennant, Bud C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135887/
https://ncbi.nlm.nih.gov/pubmed/11799172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1769-1780.2002
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