Second-Site Mutation Outside of the U(S)10-12 Domain of Δγ(1)34.5 Herpes Simplex Virus 1 Recombinant Blocks the Shutoff of Protein Synthesis Induced by Activated Protein Kinase R and Partially Restores Neurovirulence

Earlier studies have shown that herpes simplex virus type 1 (HSV-1) activated protein kinase R (PKR) but that the product of the product of the γ(1)34.5 gene binds and redirects the host phosphatase 1 to dephosphorylate the α subunit of eukaryotic translation initiation factor 2 (eIF-2α). In consequ...

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Vydáno v:	J Virol
Hlavní autoři:	Cassady, Kevin A., Gross, Martin, Gillespie, G. Yancey, Roizman, Bernard
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2002
Témata:	Virus-Cell Interactions
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11773369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.3.942-949.2002
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