The effect of ICAD-S on the formation and intracellular distribution of a nucleolytically active caspase-activated DNase

We show here that co-expression of murine CAD with either ICAD-L or ICAD-S in Escherichia coli as well as mammalian cells leads to a functional DFF complex, which after caspase-3 activation releases a nucleolytically active DNase. The chaperone activity of ICAD-S is between one and two orders of mag...

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Main Authors: Scholz, Sebastian Richard, Korn, Christian, Gimadutdinow, Oleg, Knoblauch, Michael, Pingoud, Alfred, Meiss, Gregor
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2002
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC135751/
https://ncbi.nlm.nih.gov/pubmed/12136086
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