Reverse Genetics Demonstrates that Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Essential for Replication in Cell Culture

Ebola virus, a prime example of an emerging pathogen, causes fatal hemorrhagic fever in humans and in nonhuman primates. Identification of major determinants of Ebola virus pathogenicity has been hampered by the lack of effective strategies for experimental mutagenesis. Here we exploit a reverse gen...

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Main Authors: Neumann, Gabriele, Feldmann, Heinz, Watanabe, Shinji, Lukashevich, Igor, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC135697/
https://ncbi.nlm.nih.gov/pubmed/11739705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.1.406-410.2002
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