Structural basis for Gas6–Axl signalling

Receptor tyrosine kinases of the Axl family are activated by the vitamin K-dependent protein Gas6. Axl signalling plays important roles in cancer, spermatogenesis, immunity, and platelet function. The crystal structure at 3.3 Å resolution of a minimal human Gas6/Axl complex reveals an assembly of 2:...

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Bibliographic Details
Main Authors: Sasaki, Takako, Knyazev, Pjotr G, Clout, Naomi J, Cheburkin, Yuri, Göhring, Walter, Ullrich, Axel, Timpl, Rupert, Hohenester, Erhard
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356355/
https://ncbi.nlm.nih.gov/pubmed/16362042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600912
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