Short-Sequence Tandem and Nontandem DNA Repeats and Endogenous Hydrogen Peroxide Production Contribute to Genetic Instability of Streptococcus pneumoniae

Loss-of-function mutations in the following seven pneumococcal genes were detected and analyzed: pspA, spxB, xba, licD2, lytA, nanA, and atpC. Factors associated with these mutations included (i) frameshifts caused by reversible gain and loss of single bases within homopolymeric repeats as short as...

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Detalhes bibliográficos
Main Authors: Pericone, Christopher D., Bae, Deborah, Shchepetov, Mikhail, McCool, Tera, Weiser, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135236/
https://ncbi.nlm.nih.gov/pubmed/12142409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.16.4392-4399.2002
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