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In Vivo and In Vitro Studies of Bacillus subtilis Ferrochelatase Mutants Suggest Substrate Channeling in the Heme Biosynthesis Pathway

Ferrochelatase (EC 4.99.1.1) catalyzes the last reaction in the heme biosynthetic pathway. The enzyme was studied in the bacterium Bacillus subtilis, for which the ferrochelatase three-dimensional structure is known. Two conserved amino acid residues, S54 and Q63, were changed to alanine by site-dir...

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Dades bibliogràfiques
Publicat a:J Bacteriol
Autors principals: Olsson, Ulf, Billberg, Annika, Sjövall, Sara, Al-Karadaghi, Salam, Hansson, Mats
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2002
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135158/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12081974/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.184.14.4018-4024.2002
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