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In Vivo and In Vitro Studies of Bacillus subtilis Ferrochelatase Mutants Suggest Substrate Channeling in the Heme Biosynthesis Pathway

Ferrochelatase (EC 4.99.1.1) catalyzes the last reaction in the heme biosynthetic pathway. The enzyme was studied in the bacterium Bacillus subtilis, for which the ferrochelatase three-dimensional structure is known. Two conserved amino acid residues, S54 and Q63, were changed to alanine by site-dir...

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מידע ביבליוגרפי
Main Authors: Olsson, Ulf, Billberg, Annika, Sjövall, Sara, Al-Karadaghi, Salam, Hansson, Mats
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2002
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC135158/
https://ncbi.nlm.nih.gov/pubmed/12081974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.14.4018-4024.2002
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