Nonmyeloablative Conditioning with Busulfan before Matched Littermate Bone Marrow Transplantation Results in Reversal of the Disease Phenotype in Canine Leukocyte Adhesion Deficiency

Leukocyte adhesion deficiency (LAD)–1, a primary immunodeficiency disease caused by molecular defects in the leukocyte integrin CD18 molecule, is characterized by recurrent, life-threatening bacterial infections. Myeloablative hematopoietic stem cell transplantation is the only curative treatment fo...

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Main Authors: Sokolic, Robert A., Bauer, Thomas R., Gu, Yu-Chen, Hai, Mehreen, Tuschong, Laura M., Burkholder, Tanya, Colenda, Lyn, Bacher, John, Starost, Matthew F., Hickstein, Dennis D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351378/
https://ncbi.nlm.nih.gov/pubmed/16182176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2005.07.011
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