ON THE RELATIONSHIPS OF SUBSTRATE ORIENTATION, HYDROGEN ABSTRACTION AND PRODUCT STEREOCHEMISTRY IN SINGLE AND DOUBLE DIOXYGENATIONS BY SOYBEAN LIPOXYGENASE-1 AND ITS ALA542GLY MUTANT

Recent findings associate the control of stereochemistry in lipoxygenase (LOX) catalysis with a conserved active site alanine for S configuration hydroperoxide products, or a corresponding glycine for R stereoconfiguration. To further elucidate the mechanistic basis for this stereocontrol we compare...

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Main Authors: Coffa, Gianguido, Imber, Ann N., Maguire, Brendan C., Laxmikanthan, Gurunathan, Schneider, Claus, Gaffney, Betty J., Brash, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351262/
https://ncbi.nlm.nih.gov/pubmed/16157595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M504870200
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