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Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part I. In Vitro Evaluations

A representative poly(β-amino ester) (PbAE) with biodegradable and pH-sensitive properties was used to formulate nanoparticle-based dosage form for tumor-targeted paclitaxel delivery. The polymer undergoes rapid dissolution when the pH of the medium is less than 6.5, and hence is expected to release...

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Detalhes bibliográficos
Main Authors: Shenoy, Dinesh, Little, Steven, Langer, Robert, Amiji, Mansoor
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1350920/
https://ncbi.nlm.nih.gov/pubmed/16196488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp0500420
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