Demonstration that fbiC Is Required by Mycobacterium bovis BCG for Coenzyme F(420) and FO Biosynthesis

Using the nitroimidazopyran-based antituberculosis drug PA-824 as a selective agent, transposon-generated Mycobacterium bovis strain BCG (M. bovis) mutants that could not make coenzyme F(420) were identified. Four independent mutants that could not make F(420) or the biosynthesis intermediate FO wer...

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Bibliographic Details
Main Authors: Choi, Kwang-Pil, Kendrick, Nathan, Daniels, Lacy
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Physiology and Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC134996/
https://ncbi.nlm.nih.gov/pubmed/11948155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.9.2420-2428.2002
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