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The Flavoprotein MrsD Catalyzes the Oxidative Decarboxylation Reaction Involved in Formation of the Peptidoglycan Biosynthesis Inhibitor Mersacidin

The lantibiotic mersacidin inhibits peptidoglycan biosynthesis by binding to the peptidoglycan precursor lipid II. Mersacidin contains an unsaturated thioether bridge, which is proposed to be synthesized by posttranslational modifications of threonine residue +15 and the COOH-terminal cysteine resid...

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Bibliografiske detaljer
Main Authors: Majer, Florian, Schmid, Dietmar G., Altena, Karsten, Bierbaum, Gabriele, Kupke, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134850/
https://ncbi.nlm.nih.gov/pubmed/11844751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.5.1234-1243.2002
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