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The B-Domain Lysine Patch of pRB Is Required for Binding to Large T Antigen and Release of E2F by Phosphorylation

Cell cycle-dependent, site-specific phosphorylation of the retinoblastoma protein, pRB, is mediated by cyclin-dependent kinases (CDKs) and regulates the binding of pRB to many proteins. We previously showed that the interaction of pRB with E2F on DNA was regulated by the accumulation of phosphate gr...

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Udgivet i:Mol Cell Biol
Principais autores: Brown, Vivette D., Gallie, Brenda L.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134706/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11839806/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.22.5.1390-1401.2002
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