Sequence Homology Required by Human Immunodeficiency Virus Type 1 To Escape from Short Interfering RNAs

Short interfering RNAs (siRNAs) targeting viral or cellular genes can efficiently inhibit human immunodeficiency virus type 1 (HIV-1) replication. Nevertheless, the emergence of mutations in the gene being targeted could lead to the rapid escape from the siRNA. Here, we simulate viral escape by syst...

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Bibliografiske detaljer
Main Authors: Sabariegos, Rosario, Giménez-Barcons, Mireia, Tàpia, Natalia, Clotet, Bonaventura, Martínez, Miguel Angel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346856/
https://ncbi.nlm.nih.gov/pubmed/16378959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.2.571-577.2006
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