Preliminary Mapping of a Putative Inhibitor-Binding Pocket for Human Immunodeficiency Virus Type 1 Integrase Inhibitors

Molecular modeling studies have identified a putative human immunodeficiency virus (HIV) integrase (IN) inhibitor-binding pocket for l-chicoric acid (l-CA) and other inhibitors of IN (C. A. Sotriffer, H. Ni, and A. McCammon, J. Med. Chem. 43:4109-4117, 2000). By using site-directed mutagenesis of se...

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Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Lee, Deborah J., Robinson, W. Edward
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346808/
https://ncbi.nlm.nih.gov/pubmed/16377678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.134-142.2006
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