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Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences

The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1. CDK9 is able to hyperphosphorylate the carboxyl-terminal domain (CTD) of the large...

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Udgivet i:Mol Cell Biol
Principais autores: Bourgeois, Cyril F., Kim, Young Kyeung, Churcher, Mark J., West, Michelle J., Karn, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134635/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11809800/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.4.1079-1093.2002
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