Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences

The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1. CDK9 is able to hyperphosphorylate the carboxyl-terminal domain (CTD) of the large...

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Bibliographic Details
Main Authors: Bourgeois, Cyril F., Kim, Young Kyeung, Churcher, Mark J., West, Michelle J., Karn, Jonathan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC134635/
https://ncbi.nlm.nih.gov/pubmed/11809800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1079-1093.2002
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