SP-A binds alpha(1)-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase

BACKGROUND: α1-antitrypsin and surfactant protein-A (SP-A) are major lung defense proteins. With the hypothesis that SP-A could bind α1-antitrypsin, we designed a series of in vitro experiments aimed at investigating the nature and consequences of such an interaction. METHODS AND RESULTS: At an α1-a...

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Bibliographic Details
Main Authors: Gorrini, Marina, Lupi, Anna, Iadarola, Paolo, Santos, Conceição Dos, Rognoni, Paola, Dalzoppo, Daniele, Carrabino, Natalia, Pozzi, Ernesto, Baritussio, Aldo, Luisetti, Maurizio
Format: Artigo
Language:Inglês
Published: BioMed Central 2005
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1343571/
https://ncbi.nlm.nih.gov/pubmed/16351724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-6-146
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