Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage

We demonstrate here that the E2F1 induced by DNA damage can bind to and promote the apoptotic function of p53 via the cyclin A binding site of E2F1. This function of E2F1 does not require its DP-1 binding, DNA binding, or transcriptional activity and is independent of mdm2. All the cyclin A binding...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Hsieh, Jung-Kuang, Yap, Damian, O’Connor, Daniel J., Fogal, Valentina, Fallis, Lynn, Chan, Florence, Zhong, Shan, Lu, Xin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2002
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134205/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.1.78-93.2002
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