Mitochondrial Glycerol-3-Phosphate Acyltransferase-Deficient Mice Have Reduced Weight and Liver Triacylglycerol Content and Altered Glycerolipid Fatty Acid Composition

Microsomal and mitochondrial isoforms of glycerol-3-phosphate acyltransferase (GPAT; E.C. 2.3.1.15) catalyze the committed step in glycerolipid synthesis. The mitochondrial isoform, mtGPAT, was believed to control the positioning of saturated fatty acids at the sn-1 position of phospholipids, and nu...

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Main Authors: Hammond, Linda E., Gallagher, Patricia A., Wang, Shuli, Hiller, Sylvia, Kluckman, Kimberly D., Posey-Marcos, Eugenia L., Maeda, Nobuyo, Coleman, Rosalind A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC134068/
https://ncbi.nlm.nih.gov/pubmed/12417724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8204-8214.2002
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