Hypophosphorylation of Mdm2 Augments p53 Stability
The Mdm2 protein mediates ubiquitylation and degradation of p53 and is a key regulator of this tumor suppressor. More recently, it has been shown that Mdm2 is highly phosphorylated within its central acidic domain. In order to address the issue of how these modifications might regulate Mdm2 function...
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| Veröffentlicht in: | Mol Cell Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134018/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12167711/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.17.6170-6182.2002 |
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