Rac-PAK Signaling Stimulates Extracellular Signal-Regulated Kinase (ERK) Activation by Regulating Formation of MEK1-ERK Complexes

Utilizing mutants of extracellular signal-regulated kinase 2 (ERK2) that are defective for intrinsic mitogen-activated protein kinase or ERK kinase (MEK) binding, we have identified a convergent signaling pathway that facilitates regulated MEK-ERK association and ERK activation. ERK2-Δ19-25 mutants...

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Bibliografiske detaljer
Main Authors: Eblen, Scott T., Slack, Jill K., Weber, Michael J., Catling, Andrew D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134005/
https://ncbi.nlm.nih.gov/pubmed/12167697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6023-6033.2002
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