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Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic β Cells: Role for Hepatocyte Nuclear Factor 3β and Pax6

Pancreas duodenum homeobox 1 (PDX-1) is absolutely required for pancreas development and the maintenance of islet β-cell function. Temporal and cell-type-specific transcription of the pdx-1 gene is controlled by factors acting upon sequences found within its 5′-flanking region. Critical cis-acting t...

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Autors principals: Samaras, Susan E., Cissell, Michelle A., Gerrish, Kevin, Wright, Christopher V. E., Gannon, Maureen, Stein, Roland
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC133887/
https://ncbi.nlm.nih.gov/pubmed/12052878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4702-4713.2002
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